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Synthesis of deuterium-labelled chlorpromazine and chlorpromazine metabolites

โœ Scribed by J. Cymerman Craig; L. D. Gruenke; S.-Y. Catherine Lee

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
325 KB
Volume
15
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

The eyntheeie of 2-chloro-10-(3'-dimethylaminopropyl)phenothiazine-3', 3'-d2 (Chlorpromazine-d2) and ite four major metabolitee (the mono-and didemethylated aminee, chlorpromazine sulfoxide, and chlorpromazine N-oxide), all containing the 3',3'-d2 label in > 95% ieotopic purity, ie deecribed. Considerations leading to the optimum rider and poeition of the labels are diecuaeed, and the problem of coupling the aliphatic aide-chain to the tricyclic eyetem ie avoided by utilizing the readily available Z-chloro-10-(2'-cyanoethyl)phenothiazine as starting material, 80 that the carbon skeleton of the aide-chain ie already in poeition before the ieotope ie introduced.

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