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Chlorpromazine metabolism VIII: Blood levels of chlorpromazine and its sulfoxide in schizophrenic patients

✍ Scribed by Pushkar N. Kaul; Lloyd R. Whitfield; Mervin L. Clark

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 459 KB
Volume: 65
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600650516

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✦ Synopsis

A procedure was standardized for extracting chloropromazine and its sulfoxide from the blood and for applying a recently developed fluorometric assay method to determine blood levels of these two compounds in schizophrenic patients receiving chlorpromazine therapy. The described methodology opens avenues for performing bioavailability and generic equivalence studies in humans.

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