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Synthesis of deuterium labelled diclofenac with improved isotopic enrichment

✍ Scribed by Keying Wu; Lei Tian; Hongye Li; Jian Li; Liqin Chen

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
96 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A five‐step synthesis of deuterium‐labelled diclofenac starting from 2‐phenyl[^2^H~5~] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic enrichment. It also provides a possible alternative route for the synthesis of deuterium‐labelled 4′‐hydroxydiclofenac, which is the principal human metabolite of diclofenac. Copyright © 2009 John Wiley & Sons, Ltd.

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