𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of deuterium-labelled diclofenac sodium

✍ Scribed by D. Leroy; J. Richard; J. Godbillon

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
292 KB
Volume
33
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Diclofenac sodium labelled with deuterium in the phenylacetic ring was prepared from [^2^H~5~]‐bromobenzene in a six‐step reaction. It was found to be suitable for use in pharmacokinetic and bioavailability studies in man.

📜 SIMILAR VOLUMES

Synthesis of deuterium labelled diclofen
Synthesis of deuterium labelled diclofenac with improved isotopic enrichment
✍ Keying Wu; Lei Tian; Hongye Li; Jian Li; Liqin Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 96 KB

## Abstract A five‐step synthesis of deuterium‐labelled diclofenac starting from 2‐phenyl[^2^H~5~] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic enrichment. It also provides a possible alternati

Synthesis of deuterium labelled acids
Synthesis of deuterium labelled acids
✍ A. J. Kadam; U. V. Desai; R. B. Mane 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB 👁 1 views
Synthesis of deuterium labelled trifluop
Synthesis of deuterium labelled trifluoperazine
✍ H. U. Shetty; E. M. Hawes; K. K. Midha 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB

## Abstract Procedures for the preparation of trifluoperazine with two, four and six deuterium atoms are described. Deuterium was introduced in the propylpiperazine side chain by treatment of the appropriate amide with lithium aluminium deuteride. The isotopic purity of the products was greater tha

Synthesis of deuterium-labelled trantint
Synthesis of deuterium-labelled trantinterol
✍ Hongliang Wen; Li Pan; Yingdan Zhang; Jiacheng Ma; Liqiong Qin; Maosheng Cheng 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

## Abstract Trantinterol, a selective β~2~‐adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium‐labelled trantinterol is described. The labelled trantinterol is used as an internal standard for the analysis and metabol

Synthesis of deuterium-labelled etraviri
Synthesis of deuterium-labelled etravirine
✍ Wei Wang; Wenchao Wu; Zucheng Shen; Liqin Chen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

## Abstract This study describes the synthesis of deuterium‐labelled etravirine. Etravirine labelled with six deuteriums was prepared in eight steps starting from phenol with excellent chemical purity and isotopic enrichment. It provides important internal standard for the clinical studies of etrav