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An improved synthesis of isotope labeled 6-hydroxychlorzoxazone

✍ Scribed by Zhigang Jian; Tapan Ray; Amy Wu; Lawrence Jones

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
108 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^13^C~6~]6‐Hydroxychlorzoxazone, a major P450 metabolite of chlorzoxazone, was synthesized from [^13^C~6~]benzene in an overall 18% yield. An improved procedure for converting 4‐chloro‐6‐nitrosoresorcinol to 6‐hydroxychlorzoxazone was developed, with a yield more than double that previously reported in the literature. Copyright © 2006 John Wiley & Sons, Ltd.

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