✦ LIBER ✦

Synthesis of stable isotope labeled norepinephrine

✍ Scribed by H. C. Murphy

Publisher: John Wiley and Sons
Year: 1975
Tongue: French
Weight: 229 KB
Volume: 11
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590110306

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✦ Synopsis

Abstract

Racemic norepinephrine was synthesized with three deuterium atoms on the alkyl chain. The deuteration was accomplished by D/H exchange on the intermediate, dibenzylaminodihydroxyacetophenone, followed by reduction of the keto moiety and cleavage of the benzyl‐protecting groups with deuterium gas. Noradrenalone was also shown to be a possible intermediate for the incorporation of ^18^0 into norepinephrine.

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