✦ LIBER ✦

Synthesis of stable isotope labeled 3-acetyldeoxynivalenol

✍ Scribed by Michael Bretz; Marita Beyer; Benedikt Cramer; Hans-Ulrich Humpf

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 241 KB
Volume: 49
Category: Article
ISSN: 1613-4125
DOI: 10.1002/mnfr.200500153

No coin nor oath required. For personal study only.

✦ Synopsis

Stable isotope labeled 3-acetyldeoxynivalenol (3-AcDON) was synthesized in excellent yield from deoxynivalenol as starting material. This is the first synthesis of a stable isotope labeled type-B trichothecene suitable as internal standard for HPLC-MS/MS or GC-MS analysis of trichothecene mycotoxins. The isotopic purity of the 3-d 3 -AcDON was determined to be 94.9%.

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