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Isotopic labeling of 2-desoxoparaherquamide A (PNU-141962) with deuterium

✍ Scribed by Byung H. Lee

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
113 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Modifications of marcfortine A and paraherquamide A led to the discovery of 2‐desoxoparaherquamide A (PNU‐141962, 3) which is as active as paraherquamide A and has an improved safety profile. In order to do preclinical studies, we wished to synthesize isotope‐labeled PNU‐141962. This account will describe the synthesis of [CD~3~]‐2‐desoxoparaherquamide A (4). The deuterium product was prepared in anticipation of using a similar synthesis for the preparation of the corresponding ^14^C‐ and ^3^H‐labeled products. Copyright © 2002 John Wiley & Sons, Ltd.

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