A general procedure for isotopic (deuterium) labelling of non-steroidal antiinflammatory 2-arylpropionic acids
✍ Scribed by José V. Castell; Luis A. Martínez; Miguel A. Miranda; Pilar Tárrega
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 344 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Alkaline treatment of nonsteroidal antiinflammatory 2‐arylpropionic acids in deuterium oxide led in all cases to isotopic exchange of the proton located at the α‐position of the side chain. Monodeuteration was observed in the case of carprofen, ibuprofen, ketoprofen, fenoprofen, flurbiprofen and naproxen. Additional exchange of one or two protons of the heterocyclic ring occurred in indoprofen, suprofen and tiaprofenic acid. The isotopic labelling survived under the conditions required to perform in vitro photoallergic studies (photolysis in non‐deuterated aqueous media).