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Synthesis of deuterium-labelled coenzyme Q10

✍ Scribed by Kimio Hamamura; Yoji Yamagishi; Shizumasa Kijima; Takeshi Suzuki; Yutaka Mori; Tetsuya Nakamura

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 107 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.587

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✦ Synopsis

Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of every step of the synthesis. This examination was carried out by a combination of 1 H-and 13 C-nuclear magnetic spectrometry and mass spectrometry. Further, these positions have been proved to be metabolically stable. This reagent makes simultaneous quantification of the source of coenzyme Q 10 (exogenously supplied or endogenously supplied) possible in biological samples by measurements on gas chromatography-mass spectrometry.

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