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Synthesis of [3′-14C] coenzyme Q10

✍ Scribed by Kimio Hamamura; Isao Yamatsu; Norio Minami; Yoji Yamagishi; Yuichi Inai; Shizumasa Kijima; Tetsuya Nakamura

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
88 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Radio‐labelled coenzyme Q~10~, labelled at the 3′‐position with ^14^C, was synthesized starting from natural solanesol and ethyl [3‐^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐^14^C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q~10~ in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.

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