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Synthesis of deuterated naproxens

✍ Scribed by Peter M. Gannett; Laura Miller; Jonathan Daft; Charles Locuson; Timothy S. Tracy

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 91 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1451

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✦ Synopsis

Abstract

A general scheme for the synthesis of (S)‐6‐methoxy‐2‐propanoic acid (naproxen) deuterated on the naphthyl ring, methoxy group, or both, is described. The resulting labeled naproxen derivatives are useful probes for examining atypical kinetics displayed by cytochrome P450 2C9. Copyright © 2007 John Wiley & Sons, Ltd.

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