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Synthesis of Deuterated Mevalonolactone Isotopomers

✍ Scribed by Jeroen S. Dickschat; Christian A. Citron; Nelson L. Brock; Ramona Riclea; Henning Kuhz

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
217 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

A synthetic route was developed for the preparation of deuterated mevalonolactones. Using low‐cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6,6,6‐^2^H~3~]mevalonolactone, [4,4,6,6,6‐^2^H~5~]mevalonolactone, [5,5‐^2^H~2~]mevalonolactone, [5,5,6,6,6‐^2^H~5~]mevalonolactone, and [2,2,6,6,6‐^2^H~5~]mevalonolactone is described.

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