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Synthesis of deuterated clenbuterol

✍ Scribed by Ole Jørgensen; Helge Egsgaard; Elfinn Larsen

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 464 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199611)38:11<1007::aid-jlcr918>3.0.co;2-4

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✦ Synopsis

The synthesis of D,-clenbuterol (I) and D,-clenbuterol ( ) is described. D,-clenbuterol (I) was prepared from 4-amino-a-bromo-3,5-dichloroacetophenone by reaction with D,-tert-butylamine followed by reduction of the keto group with NaBH,. D,-clenbuterol (11) was prepared from 4-amino-cl-tert-butylamino-3,5-dichloroacetophenone by an exchange reaction of the a-hydrogens with deuterium followed by reduction of the keto group with NaBD,. The eventual products were characterized by mass spectrometry and NMR.

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