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Synthesis of radiolabelled clenbuterol analogues

✍ Scribed by Graham G. Pegg; Martin N. Sillence; Madonna J. Sleeman; Derek B. Lindsay

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
327 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Oxidation of clenbuterol 1a with pyridinium chlorochromate yielded 4‐amino‐3,5‐dichloro‐α‐tert‐butylaminoacetophenone 5. Tritiated clenbuterol 1b was produced by reduction of 5 with sodium [^3^H]borohydride. Radioiodination of the clenbuterol precursor [2‐tert‐butylamino‐1‐(4‐aminophenyl)‐ethanol] 2 yielded [2‐tert.‐butylamino‐1‐(4‐amino‐3‐[^125^I] iodophenyl)‐ethanol] 3b.

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