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Synthesis of mevalonolactone-2,3-13C2

✍ Scribed by Joseph I. Degraw; Ieaki Uemura

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
115 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of mevalonolactone with ^13^C‐labels at positions 2 and 3 is reported. Hydrolysis of methyl 3‐hydroxy‐3‐methyl‐5,5‐dimethoxy‐valerate‐2,3‐^13^C~2~ to the aldehydo acid followed by reduction with sodium borohydride yielded the title compound. The material is useful as a substrate in biosynthetic studies using ^13^C‐NMR as an analytical tool.

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