Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave
Synthesis of methyl [2-13C-2,2-d2]- and [3-13C-3,3-d2]tetracosanoate
โ Scribed by J. George Pomonis; Heldur Hakk
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 331 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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S p e c i f i c a l l y l a b e l e d , o p t i c a l isomers of a l a n i n e were synthesized from acetic-13C2 a c i d by a six-tjtep procedure with y i e l d s of 37-38% of t h e o p t i c a l l y a c t i v e m a t e r i a l .
## Abstract The synthesis of mevalonolactone with ^13^Cโlabels at positions 2 and 3 is reported. Hydrolysis of methyl 3โhydroxyโ3โmethylโ5,5โdimethoxyโvalerateโ2,3โ^13^C~2~ to the aldehydo acid followed by reduction with sodium borohydride yielded the title compound. The material is useful as a sub