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Synthesis of deuterated dihydrochalcones

✍ Scribed by Daniel J. Comeskey; Janine M. Cooney; Daryl D. Rowan

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 128 KB
Volume: 49
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1057

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✦ Synopsis

The dihydrochalcones phloretin and phloridzin are major phenolic constituents of apple fruit. Phloretin-d 4 , deuterated at both the a and b positions, was prepared by hydrogenolysis of naringenin and by deuterium exchange from unlabelled phloretin using Pd/C and sodium formate with methanol-d 1 as the source of deuterium. Deuterated derivatives of the glycosides, phloridzin and naringin dihydrochalcone, were similarly prepared.

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