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Synthesis of Curacin A: A Powerful Antimitotic from the Cyanobacterium Lyngbya majuscula

โœ Scribed by White, James D.; Kim, Tae-Seong; Nambu, Mitch

Book ID
119957421
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
173 KB
Volume
117
Category
Article
ISSN
0002-7863

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ChemInform Abstract: Synthetic Study on
ChemInform Abstract: Synthetic Study on Curacin A: A Novel Antimitotic Agent from the Cyanobacterium Lyngbya majuscula.
โœ T. ONODA; R. SHIRAI; Y. KOISO; S. IWASAKI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 2 views

The title compound (XV) is synthesized via highly stereoselective allylation of the aldehyde (VIII), Wittig reaction of the phosphonium salt (XI) with the aldehyde (XII), and condensation of the amino thiol (XIII) with the acid (XIV). -(ONODA, T.;