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Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula

โœ Scribed by Jing-Yu Lai; Jurong Yu; Belew Mekonnen; J.R. Falck

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
185 KB
Volume
37
Category
Article
ISSN
0040-4039

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The title compound (XV) is synthesized via highly stereoselective allylation of the aldehyde (VIII), Wittig reaction of the phosphonium salt (XI) with the aldehyde (XII), and condensation of the amino thiol (XIII) with the acid (XIV). -(ONODA, T.;