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Synthesis of CD3-labelled 3-methoxytyramine, normetanephrine and metanephrine for use as internal standards in mass fragmentographic analyses

✍ Scribed by Frits A. J. Muskiet; Stanislav Pavel; Gerrie J. Stob; Henk Elzinga

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
328 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of CD~3~‐labelled 3‐methoxytyramine, normetanephrine and metanephrine from their parent catecholamines is described. The syntheses include N‐maleylation, O‐methylation by dimethylsulfate‐D~6~, removal of the protecting group by acid hydrolysis and partial purification of the reaction product. Examples of the use of the deuterium labelled O‐methylated catecholamine metabolites as internal standards for the ammonia chemical ionisation mass fragmentographic determination of their naturally occurring analogs in urine, are given.

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