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Synthesis of deuterium-labelled drugs, of abuse for use as internal standards in, quantification by selected ion monitoring. II. Deuterium-labelled benzodiazepines: Chlordiazepoxide, demethyldiazepam, diazepam, and oxazepam

✍ Scribed by Allison F. Fentiman Jr.; Rodger L. Foltz

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
254 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Four deuterium‐labelled benzodiazepines were prepared for use as internal standards in the quantification of chlordiazepoxide, demethyldiazepam, diazepam, and oxazepam at low levels in body fluids by selected ion monitoring. The method described provides a way to introduce cleanly and in high isotopic purity five deuterium atoms into each drug.

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Synthesis of deuterium-labelled drugs of
Synthesis of deuterium-labelled drugs of abuse for use as internal standards in quantification by selected ion monitoring. I. Methamphetamine; 2,5-dimethoxy-4-methylamphetamine (DOM); phencyclidine (PCP); and methaqualone
✍ Allison F. Fentimanjr; Rodger L. Foltz 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 457 KB 👁 1 views

## Abstract Four deuterium‐labelled compounds were prepared for use as internal standards in the quantification of methamphetamine, DOM, PCP, and methaqualone at low levels in body fluids by selected ion monitoring. The need for standards containing more than three deuterium atoms per molecule and