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Synthesis of deuterated arylalkanoic acids for use as internal standards in gas chromatography/mass spectrometry assays for non-steroidal anti-inflammatory drugs

✍ Scribed by M. Dawson; C. M. McGee; M. D. Smith; J. H. Vine


Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
251 KB
Volume
27
Category
Article
ISSN
0022-2135

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Trideuterated 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL-d 3 ) was synthesized from tetradeuterated catechol. After derivatization with N-methyl-N-trimethylsilyltrifluoroacetamide, the identity of DOPEGAL-d 3 was confirmed by comparison with unlabeled DOPEGAL by gas chromatography-mass spectrometry