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Synthesis and Use of Deuterated 3,4-Dihydroxyphenylglycolaldehyde as an Internal Standard for Determination of Dopegal in Brain Tissue by Gas Chromatography–Mass Spectrometry

✍ Scribed by Shu Wen Li; Vincent T. Spaziano; William H. Elliott; William J. Burke

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 166 KB
Volume: 24
Category: Article
ISSN: 0045-2068
DOI: 10.1006/bioo.1996.0015

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✦ Synopsis

Trideuterated 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL-d 3 ) was synthesized from tetradeuterated catechol. After derivatization with N-methyl-N-trimethylsilyltrifluoroacetamide, the identity of DOPEGAL-d 3 was confirmed by comparison with unlabeled DOPEGAL by gas chromatography-mass spectrometry (GC-MS); they have the same pattern of mass fragmentation. The deuterated DOPEGAL was used as an internal standard for the determination of DOPEGAL in human locus ceruleus by GC-MS in the selected-ionmonitoring mode.

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