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Synthesis of carbon-14 labeled 4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one

✍ Scribed by S. R. Prakash; R. L. Ellsworth; H. E. Mertel

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
352 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

Two different syntheses of (z), one labeled with carbon-14 in the quinonoid ring and the other in the phenyl ring are described. methoxy benzenethiol yielded ( I ) , which was methoxylated to provide a mixture of isomers (&) and (8). isomers followed by bromination of (2) gave (2). Thiocyanation of p-[U-14C]anisidine provided (x), which was hydrolysed to give labeled aminothiol (E); the latter was condensed with 2-bromo-6-methoxy-p-benzoquinone to afford (2).

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