Synthesis of a series of carbon-14 labelled 4-aminoquinazolines and quinazolin-4 (3H)-ones
✍ Scribed by Nader Saemian; Omid Khalili Arjomandi; Gholamhossein Shirvani
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- French
- Weight
- 102 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
4‐Aminoquinazolines and quinazolin‐4 (3H)‐ones, both labelled with carbon‐14 in the 4‐position, were prepared from 2‐aminobenzonitrile‐[cyano‐^14^C] and 2‐aminobenzoic acid‐[carboxy ‐^14^C] or 2‐amino‐ benzamide‐[carboxy ‐^14^C], respectively, using rapid, one‐pot procedures under microwave enhanced conditions. Copyright © 2009 John Wiley & Sons, Ltd.
📜 SIMILAR VOLUMES
## Abstract Some new derivatives 7‐chloro‐2‐[2‐(2,6‐dichlorophenyl)amino]benzyl‐3‐[4‐(2‐substituted phenyl‐4‐oxo‐ thiazolidin‐3‐yl)phenyl]sulfonamido‐quinazolin‐4(3__H__)‐ones 5a–5l were synthesized from 2‐[2‐(2,6‐dichloro‐phenyl)amino]phenyl acetic acid via acid chloride, benzoxazinone, amino quin
Two different syntheses of (z), one labeled with carbon-14 in the quinonoid ring and the other in the phenyl ring are described. methoxy benzenethiol yielded ( I ) , which was methoxylated to provide a mixture of isomers (&) and (8). isomers followed by bromination of (2) gave (2). Thiocyanation of