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Synthesis of benzo-type prostaglandin analogs

✍ Scribed by Akihiko Sugie; Hiromi Shimomura; Junki Katsube; Hisao Yamamoto

Publisher: Elsevier Science
Year: 1977
Tongue: French
Weight: 189 KB
Volume: 18
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)83065-3

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✦ Synopsis

In recent years, a number of modified prostaglandins(PG) have been synthesized at several laboratories from synthetic and pharmaceutical points of view. 2) As part of our program of structural modification on PG, attempts have been made to synthesize benzo-type PG derivatives, a new class of PG analogs.

We wish to describe here the synthesis of lO,ll-benzo-PGA2 1 and its 13,14dihydro derivative 2.

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