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Synthesis of azepane scaffolds on solid support for combinatorial chemistry

✍ Scribed by Laurence Gauzy; Yves Le Merrer; Jean-Claude Depezay; François Clerc; Serge Mignani

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
243 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Enantiopure C2-symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry. The key step involves Rink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide.

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