Enantiopure C2-symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry. The key step involves Rink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide.
Synthesis of two Conformationally Restricted Piperazine Scaffolds for Combinatorial Chemistry
β Scribed by Till Opatz
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 126 KB
- Volume
- 2004
- Category
- Article
- ISSN
- 1434-193X
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Combinatorial chemistry opens up new possibilities for research in medicinal chemistry in both the search for lead structures and their rapid optimization.['] Nevertheless, though many peptides are already the first milestones along this path, the optimization of sequences suitable for their combina