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Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry

✍ Scribed by Montserrat del Fresno; Jordi Alsina; Miriam Royo; George Barany; Fernando Albericio

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
306 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Diketopiperazines, which are cyclic dipeptides, are often formed by a side reaction of solid-phase peptide synthesis. Using the new "Backbone Amide Linker," this chemistry can be conveniently harnessed for the intentional preparation of diketopiperazines. These products will be useful scaffolds for combinatorial chemistry, since they incorporate three different points of diversity: both amino acid side-chains and one (of the two) amide bonds.

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