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From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole-Based Scaffold for Combinatorial Chemistry

✍ Scribed by David Orain; Guido Koch; Rudolf Giger


Publisher
John Wiley and Sons
Year
2004
Weight
56 KB
Volume
35
Category
Article
ISSN
0931-7597

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Preparation of new N6, 9-disubstituted 2
✍ Giuliana Biagi; Irene Giorgi; Oreste Livi; Federica Pacchini; Valerio Scartoni; πŸ“‚ Article πŸ“… 2004 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 160 KB

## Abstract A suitably substituted pyrimidine **1** was converted to a number of title compounds. Nucleophilic substitu tion involving the chlorine atoms in **1** by treatment with phenylmethanethiol yielded **2** or **3**, depending on the reaction temperature. Treatment of **3** with an amine aff