✦ LIBER ✦

Solid-phase synthesis of small molecule libraries using double combinatorial chemistry

✍ Scribed by John Nielsen; Flemming R. Jensen

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 196 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00219-0

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✦ Synopsis

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis.

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