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Synthesis of a Conformationally Flexible β-Hairpin Mimetic

✍ Scribed by Reinhard W. Hoffmann; Ulrich Schopfer; Gerhard Müller; Trixi Brandl

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
270 KB
Volume
85
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Rational conformation design led us to a synthesis of the ω‐amido‐undecenamide 4, which was shown by theoretical means (simulated annealing techniques) and by NMR and IR spectroscopy to have a high tendency to populate a conformation corresponding to a natural β‐II′‐type hairpin, despite possessing a conformationally fully flexible open‐chain backbone.

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