Peptide side chains play critical roles in the event of molecular recognition. In order to study the bioactive conformation of parent peptides, a concise and straightforward five-step synthesis of [5.5]-bicyclic reverse turn dipeptide mimetic scaffolds with side chain functionality at the i+1 and i
Synthesis of conformationally constrained β-turn thiazolidine mimetic
✍ Scribed by Paolo Grieco; Pietro Campiglia; Isabel Gomez-Monterrey; Ettore Novellino
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 89 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A dipeptide analog b-turn mimetic with fixed configuration at a-carbons of two amino acid residues in structure type b-turn has been synthesized starting from L-phenilalanine and L-cysteine in short steps.
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