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Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics

✍ Scribed by Wei Qiu; Xuyuan Gu; Vadim A Soloshonok; Michael D Carducci; Victor J Hruby

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
93 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Peptide side chains play critical roles in the event of molecular recognition. In order to study the bioactive conformation of parent peptides, a concise and straightforward five-step synthesis of [5.5]-bicyclic reverse turn dipeptide mimetic scaffolds with side chain functionality at the i+1 and i + 2 positions has been developed. In the bicyclic structure, two dihedral angles ( 2 and 3 ) are greatly restricted.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Stereoselective Syn
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