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Synthesis of constrained bicyclic dipeptide mimetics

✍ Scribed by M.Arshad Siddiqui; Patrice Préville; Micheline Tarazi; Scott E. Warder; Paul Eby; Elise Gorseth; Karen Puumala; John DiMaio

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
198 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient synthesis of constrained bicyclic peptidomimetics of (R)-Phe-Pro dipeptide is described. Such mimetics may provide an opportunity to develop inhibitors of thrombin possessing the desired pharmacological features.

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