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Synthesis of 9-(β-d-arabinofuranosyl)guanine using whole cells ofEscherichia coli

✍ Scribed by A. I. Zinchenko; V. N. Barai; S. B. Bokut; E. I. Kvasyuk; I. A. Mikhailopulo

Book ID
104650970
Publisher
Springer
Year
1990
Tongue
English
Weight
308 KB
Volume
32
Category
Article
ISSN
1432-0614

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✦ Synopsis

Synthesis of 9-(fl-D-arabinofuranosyl)guanine (ara-G) from 1-(fl-o-arabinofuranosyl)cytosine (ara-C) and guanine, guanosine or 2'-deoxyguanosine (dG) by glutaraldehyde-treated Escherichia coli BM-11 cells is described. It is shown that the concentration of phosphate ions, molar ratio of substrates and pH of the reaction medium are factors affecting product yield. Under optimum conditions ara-G was produced in the reaction mixture in a yield of 63%-65% based on dG as the best source of guanine base. The yield of isolated ara-G was 48%-53%.

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