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A New Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)guanine (araF-G)

✍ Scribed by Elzagheid, Mohamed I.; Viazovkina, Ekaterina; Damha, Masad J.


Book ID
111696304
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
209 KB
Volume
22
Category
Article
ISSN
0732-8311

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📜 SIMILAR VOLUMES


Synthesis of [2-14C]-1-(2-deoxy-2-fluoro
✍ Hemant K. Misra; Leonard I. Wiebe; Edward E. Knaus 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 422 KB 👁 1 views

The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (

Synthesis of 1-(2-deoxy-2-fluoro-β-D-ara
✍ J. E. Swigor; K. A. Pittman 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 232 KB 👁 1 views

The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C