✦ LIBER ✦
Enantiospecific synthesis of the potent anti-herpetic carbocyclic 9-(2′deoxy-2′-flouro-β-D-arabinofuranosyl) guanine (+)CAFG from arsiteromycin
✍ Scribed by Alan D Borthwick; Keith Biggadike; Stuart Holman; C.L. Mo
- Book ID
- 104226658
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 193 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
SlM4UZ: A ten-step enantiospecific synthesis of carkocyclic 9-(2'-deoxy-2'-fluoro-S-D-arabinofuramsyl)guanine (lo), (+) C-AEG, fran Aristerasycin is described. -We recently reported the synthesis of a new anti-herpes agent (2) carboqclic 9-(2'-deoxy-2'-flmr* p-D-arabinofuraucsyl)gua.nine (g).1,2 This fluorccarbocyclic nucleoside is highly active against Herpes Siqlex virus type 1 (HEW-l) and type 2