✦ LIBER ✦

Synthesis of 9-(hydroxyalkylamino)guanines, novel antiviral acyclonucleosides

✍ Scribed by M.R. Harnden; R.L. Jarvest

Book ID: 104217691
Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 177 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82249-2

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✦ Synopsis

9-Aminoguanine (3) has been prepared and used as an intermediate in syntheses of 9-(3-hydroxypropylanino)guazne (id) and 9-[3-hydroxy-2-(hydroxymethyl)propylanino]guanine (le), the first reported members of a new series of antiviral acyclonucleosides. Certain 9-alkylated guanines such as acyclovirl, ganciclovirl and 9-[A-hydroxy-3-

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