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Synthesis of 9-(3-hydroxypropoxy)guanine, a novel antiviral acyclonucleoside

โœ Scribed by M.R. Harnden; A. Parkin; P.G. Wyatt


Book ID
104216437
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
227 KB
Volume
29
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of 9-(hydroxyalkylamino)guanin
โœ M.R. Harnden; R.L. Jarvest ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 177 KB

9-Aminoguanine (3) has been prepared and used as an intermediate in syntheses of 9-(3-hydroxypropylanino)guazne (id) and 9-[3-hydroxy-2-(hydroxymethyl)propylanino]guanine (le), the first reported members of a new series of antiviral acyclonucleosides. Certain 9-alkylated guanines such as acyclovirl,

An improved synthesis of the antiviral a
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Alkylation of 2-amino-6-chloropurine with 5-(2-bromoethyl)-2,2dimethyl-1,3-dioxan ( 7) and subsequent acid hydrolysis provides an improved procedure for synthesis of the antiviral acyclonucleoside 9-(4-hydroxy-3hydroxymethylbut-I-yl)guanine (3).