The synthesis is described of (fi)-6a-oxo-6,9-methano-L5-hydroxyprosta-5,13-dienoic acids as stable analogues of prostacyclin with blood platelet aggregation inhibiting activity. Considerable effort has been devoted to the preparation of chemically stable analogues prostacyclin.' We report here the
Synthesis of 6,7-dehydro-5-oxo-prostaglandin I1: A stable analog of prostacyclin
✍ Scribed by Hisao Nishiyama; Kiyotaka Ohno
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 190 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
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A bridged bicyclic coml~)und 8. the key intermediate for the synthesis of huperzine A (1). was prepared by asymmetric palladium-calalyzed bicycloannulation of g-keto ester 2. A variety of chhal ligands and reaction conditions were tcsled. 52% ee values were observed.
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