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Studies on asymmetric synthesis of hyperzine A 1. Palladium-catalyzed asymmetric bicycloannulation of 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic esters

✍ Scribed by Xu-Chang He; Bin Wang; Donglu Bai

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
234 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A bridged bicyclic coml~)und 8. the key intermediate for the synthesis of huperzine A (1). was prepared by asymmetric palladium-calalyzed bicycloannulation of g-keto ester 2. A variety of chhal ligands and reaction conditions were tcsled. 52% ee values were observed.

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A Chemical Study of Burley Tobacco Flavo
A Chemical Study of Burley Tobacco Flavour (Nicotiana tabacumL.) V. Identification and Synthesis of the Novel Terpenoid Alkaloids 1, 3, 6, 6-Tetramethyl-5, 6, 7, 8-tetrahydro-isoquinolin-8-one and 3, 6, 6-Trimethyl-5,6-dihydro-7H-2-pyrindin-7-one
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## Abstract GLC. allowed the isolation of 1, 3, 6, 6‐tetramethyl‐5, 6, 7, 8‐tetrahydro‐isoquinolin‐8‐one (__A__) and 3,6,6‐trimethyl‐5,6‐dihydro‐__7H__‐2‐pyrindin‐7‐one (__D__) from __Burley__ tobacco condensate (about 0.1% each). The structures and syntheses of these novel terpenoid alkaloids are