✦ LIBER ✦

Synthesis of new stable analogues of prostacyclin: (±)-6a-oxo-6,9-metrano-15-hydroxyprosta-5,13-dienoic acids

✍ Scribed by C.W. Bird; H.I. Butler; M.P.L. Caton; E.C.J. Coffee; C.J. Hardy; T.W. Hart; H.J. Mason

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 203 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)89303-x

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis is described of (fi)-6a-oxo-6,9-methano-L5-hydroxyprosta-5,13-dienoic acids as stable analogues of prostacyclin with blood platelet aggregation inhibiting activity. Considerable effort has been devoted to the preparation of chemically stable analogues prostacyclin.' We report here the synthesis of a new class of biologically active of analogues in which the 6,9 ether linkage of 11-deoxyprostacyclin is replaced by a carbonyl group to give the stable enone (15). -Scheme1

📜 SIMILAR VOLUMES

Synthesis of 6,9α-oxido-11α, 15α-dihydro

Synthesis of 6,9α-oxido-11α, 15α-dihydroxyprosta-(E)5, (E)13-dienoic acid, an isomer of PGI2 (vane's PGX)

✍ E.J. Corey; Istvan Székely; Christopher S. Shiner 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 236 KB

Synthesis of Methyl (5S,6R,7E,9E,11Z,13E

Synthesis of Methyl (5S,6R,7E,9E,11Z,13E,15S)-16- (4-Fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate (V), an Analogue of 15R-Lipoxin A4.

✍ Eifion D. Phillips; Hui-Fang Chang; Christopher R. Holmquist; John P. McCauley 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 95 KB 👁 1 views

The use of immobilized ligands and [125I

The use of immobilized ligands and [125I] protein a for immunoassays of thromboxane B2, prostaglandin D2, 13,14-dihydro-prostaglandin E2, 5,6-dihydro-prostaglandin I2, 6-keto-prostaglandin F1α, 15-hydroxy-9α,11α(epoxymethano)prosta5, 13-dienoic acid and 15-hydroxy-11α,9α(epoxymethano)prosta-5,13-dienoic acid

✍ Lawrence Levine; Iftekhar Alam; John J. Langone 📂 Article 📅 1979 🏛 Elsevier Science ⚖ 840 KB

A simple and efficient synthesis of (7E,

A simple and efficient synthesis of (7E, 9E, 11Z, 13E)-(5S, 6R, 15S)-trihydroxyeicosatetraenoic acid (6R-lipoxin A)

✍ E.J. Corey; Wei-guo Su; Martin B. Cleaver 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 253 KB

Stereoselective Total Synthesis of 5(S),

Stereoselective Total Synthesis of 5(S), 6(R), 15(S)-Trihydroxy-7(E), 9(E), 11(Z),13(E)-Eicosatetraenoic Acid (Lipoxin A)

✍ J.S Yadav; D.K Barma; Dinah Dutta 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 418 KB

ChemInform Abstract: Stereoselective Tot

ChemInform Abstract: Stereoselective Total Synthesis of 5(S), 6(R), 15(S)-Trihydroxy-7(E), 9(E), 11(Z), 13(E)-Eicosatetraenoic Acid (Lipoxin A).

✍ J. S. YADAV; D. K. BARMA; D. DUTTA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views