✍ Scribed by Reinhard Troschütz; Alexander Karger
No coin nor oath required. For personal study only.
The synthesis of 6‐phenyl‐atevirdine (17), a lipophilic derivative of the potent HIV‐1 reverse transcriptase inhibitor atevirdine (1), is described. The title compound was prepared from dithioacetale 2 via keteneaminal 4 and the nitropyridine derivative 10. Unexpectedly, no anti HIV activity was observed for the novel atevirdine derivative 17. The key intermediates 6, 8 and 10 could also be prepared from keteneaminal 18 via chloropyridines 22–24.
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