An efficient synthesis of (SS,12S)-diHETE was realized by a Pd-Cu catalysed coupling
Synthesis of 5S,12S - diHETE (LTBx)
β Scribed by Julian Adams; Yves Leblanc; Joshua Rokach
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 205 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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The first total synthesis of (1 lR, 12s) diHETE IS reported. The key step is the highly chemioand stereaselective osmylation of a double bond in a trienyne system selectively complexed by an Fe(CO)3 group.
The fist highly practical stereocontrolled synthesis of the four diastereoisomeric (5,6)-DiHETEs is described using the acetonides of D-and L-glyceraldehyde as a source of chirality. Their spectral and physico-chemical properties are also described. Although known for some years as non enzymatic hy
Enantiospecific syntheses of the ZO-and both 19-hydroxy metabolites of 12(S)-HETE were accomplished using readily available, chiral precursors. Recently, a new metabolite of 12(S)-hydroxyeicosatetraenoic (12-HETE) acid (1) was isolated from the coincubation of human platelets and neutrophils with ar