𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Total synthesis of (11R, 12S)-diHETE

✍ Scribed by Agnès Gigou; Jean-Pierre Beaucourt; Jean-Paul Lellouche; René Gree

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
205 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The first total synthesis of (1 lR, 12s) diHETE IS reported. The key step is the highly chemioand stereaselective osmylation of a double bond in a trienyne system selectively complexed by an Fe(CO)3 group.

📜 SIMILAR VOLUMES

Synthesis of 5S,12S - diHETE (LTBx)
Synthesis of 5S,12S - diHETE (LTBx)
✍ Julian Adams; Yves Leblanc; Joshua Rokach 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 205 KB
A new efficient synthesis of (5S,12S)-Di
A new efficient synthesis of (5S,12S)-DiHETE
✍ D. Chemin; M. Alami; G. Linstrumelle 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 235 KB

An efficient synthesis of (SS,12S)-diHETE was realized by a Pd-Cu catalysed coupling

Asymmetric Synthesis of (+)-(11R,12S)-Me
Asymmetric Synthesis of (+)-(11R,12S)-Mefloquine Hydrochloride
✍ Zhi-Xiang XIE; Lu-Zhong ZHANG; Xiao-Juan REN; Shi-Yang TANG; Ying LI 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 1 views

## Abstract The asymmetric synthesis of (+)‐(11__R__,12__S__)‐mefloquine hydrochloride, an antimalarial drug, was accomplished from commercially available 2‐trifluoromethylaniline, ethyl 4,4,4‐trifluoroacetoacetate and cyclopentanone in 7 steps with a 14% overall yield. The key steps were proline‐c

Stereospecific total synthesis of (5.6)-
Stereospecific total synthesis of (5.6)-dihete isomers
✍ Claude Kugel; Jean-Paul Lellouche; Jean-Pierre Beaucourt; Gilles Niel; Jean-Pier 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 273 KB

The fist highly practical stereocontrolled synthesis of the four diastereoisomeric (5,6)-DiHETEs is described using the acetonides of D-and L-glyceraldehyde as a source of chirality. Their spectral and physico-chemical properties are also described. Although known for some years as non enzymatic hy

Total synthesis of 11(R,S)-HETE (13)
Total synthesis of 11(R,S)-HETE (13)
✍ George Just; Corinne Luthe 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 192 KB

An expedient preparation of ll(R,S)-HETE which may be adapted to the synthesis of 11(S)-HETE is described. Corey and Kang' recently described the synthesis of 11(R)-HETE (s), which could serve as a precursor to the corresponding hydroperoxide 14 or peroxy-radical Is, substances implicated in prosta