## Abstract The asymmetric synthesis of (+)โ(11__R__,12__S__)โmefloquine hydrochloride, an antimalarial drug, was accomplished from commercially available 2โtrifluoromethylaniline, ethyl 4,4,4โtrifluoroacetoacetate and cyclopentanone in 7 steps with a 14% overall yield. The key steps were prolineโc
โฆ LIBER โฆ
ChemInform Abstract: Asymmetric Synthesis of (+)-(11R,12S)-Mefloquine Hydrochloride.
โ Scribed by Zhi-Xiang Xie; Lu-Zhong Zhang; Xiao-Juan Ren; Shi-Yang Tang; Ying Li
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 32 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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