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Stereospecific total synthesis of (5.6)-dihete isomers

✍ Scribed by Claude Kugel; Jean-Paul Lellouche; Jean-Pierre Beaucourt; Gilles Niel; Jean-Pierre Girard; Jean-Claude Rossi

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
273 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

The fist highly practical stereocontrolled synthesis of the four diastereoisomeric (5,6)-DiHETEs is described using the acetonides of D-and L-glyceraldehyde as a source of chirality. Their spectral and physico-chemical properties are also described.

Although known for some years as non enzymatic hydrolysis product of ( 5S,6S )-LTb, the diastereoisomeric ( $6 )-dihydroxy -7,9 -trans -11,14 -cis-eicosatetraenoic acids ( 5,6_DiHETBsl)

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