Synthesis of 4-dihydroxyboryl-2-[18F]fluoro-L-phenylalanine
✍ Scribed by O. Eskola; J. Vähätalo; P. Lehikoinen; J. Bergman; S. Forsback; O. Solin
- Book ID
- 112132754
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 146 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract An alternative procedure to produce 4‐dihydroxyboryl‐2‐[^18^F]fluorophenylalanine ([^18^F]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high‐specific activity electrophilic radiofluorine is produced using a post‐target conversio
The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was
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